Histological analysis of the effect of global HPC on retinal ischemic damage.

Total retinal and retinal layer thicknesses (in µm) in non-ischemic or ischemic eyes without or with global HPC. Retinal ischemia induced a significant decrease in total retinal, ONL, INL and IPL thickness, and in GCL Brn3a(+) cell number. The alterations in total retinal, INL, and IPL (but not ONL) thickness, and in retinal ganglion cell number were partially prevented by global HPC, which showed no effects in non-ischemic eyes on these parameters. Data are mean ± SEM (n = 5 eyes per group).*P**PapbpPS, photoreceptor outer and inner segment; OPL, outer plexiform layer; ONL, outer nuclear layer; IPL, inner plexiform layer; INL, inner nuclear layer.