RNA-Seq of KRAS-regulated genes in human cell lines

Human cell lines were treated with a KRASG12C inhibitor or tamoxifen to activate KRAS for different time points. Then RNA was extracted for gene expression analysis to assess the role of KRAS signalling on immune-related genes. RNA-Seq of two KRASG12C-mutant lung cancer cell lines and one normal lung cell line

本数据集的实验设计为：使用KRASG12C抑制剂（KRASG12C inhibitor）或他莫昔芬（tamoxifen）处理人类细胞系，在不同时间点激活KRAS信号通路；随后提取总RNA进行基因表达分析，以探究KRAS信号通路对免疫相关基因的调控作用。数据集涵盖两株KRASG12C突变型肺癌细胞系与一株正常肺细胞系的RNA测序（RNA-Seq）数据。