Silicon Amine Reagents for the Photocatalytic Synthesis of Piperazines from Aldehydes and Ketones

Silicon
amine protocol (SLAP) reagents for photocatalytic cross-coupling
with aldehydes and ketones to form N-unprotected
piperazines have been developed. This blue light promoted process
tolerates a wide range of heteroaromatic, aromatic, and aliphatic
aldehydes and structurally and stereochemically complex SLAP reagents.
It provides a tin-free alternative to SnAP (tin amine protocol) reagents
for the synthesis of substituted piperazines.

本研究开发了可与醛、酮发生光催化交叉偶联反应以生成N-未保护哌嗪的硅胺协议（Silicon Amine Protocol, SLAP）试剂。该蓝光促进的反应可兼容多种杂芳族、芳香族及脂肪族醛，以及结构与立体化学复杂度各异的SLAP试剂。相较于锡胺协议（Tin Amine Protocol, SnAP）试剂，其为取代哌嗪的合成提供了无锡替代方案。