Supplementary file 1_Eligibility for Lung Cancer Screening in Switzerland: A Comparative Analysis of Three Data Sources From Lausanne and the Canton of Vaud.docx

ObjectivesThis study aimed to estimate the proportion of individuals potentially eligible for lung cancer screening in Lausanne, canton of Vaud, Switzerland, and its associations with key sociodemographic and health-related covariates.
MethodsWe analyzed self-reported, cross-sectional data from three sources: Lausanne cohort 65+ (2014; n = 1,678; ages 65–70), CoLaus|PsyCoLaus (2014–2017; n = 3,839; ages 50–79), and the Swiss Health Survey (2022, representative of Vaud, ages 50–79). Eligibility was defined by the 2021 United States Preventive Services Task Force criteria. Screening eligibility prevalence was estimated separately in each dataset, and eligible and non-eligible participants were compared using bivariate hypothesis tests.
ResultsEligibility was 18.2% in the Lc65+ cohort, 16.0% in CoLaus, and 14.4% in the Swiss Health Survey. Among eligible individuals, the prevalence of current smoking was 58.7% in Lc65+, 60.1% in the Swiss Health Survey, and 64.9% in CoLaus. Eligible participants tended to have a higher burden of comorbidities and social vulnerabilities, including cardiovascular disease, metabolic syndrome, depression, and lower education or income; statistically significant differences varied by dataset.
ConclusionIn this Swiss population, about one in six adults met lung cancer screening criteria. Findings highlight the need for combining early detection with tobacco cessation, health promotion, and equitable access to care.

研究目的
本研究旨在估算瑞士沃州洛桑地区符合肺癌筛查准入条件的潜在人群比例，并分析其与关键社会人口学特征及健康相关协变量的关联。

研究方法
本研究分析了来自三个数据源的自我报告横断面数据：洛桑65岁及以上队列（简称Lc65+，2014年，样本量n=1,678，年龄范围65~70岁）、CoLaus|PsyCoLaus队列（2014~2017年，样本量n=3,839，年龄范围50~79岁）以及瑞士健康调查（Swiss Health Survey，2022年，代表沃州人群，年龄范围50~79岁）。筛查准入资格依据2021年美国预防服务工作组（United States Preventive Services Task Force）标准划定。本研究分别对各数据集的肺癌筛查准入患病率进行估算，并采用双变量假设检验对比符合与不符合准入条件的研究对象。

研究结果
Lc65+队列的肺癌筛查准入率为18.2%，CoLaus队列的准入率为16.0%，瑞士健康调查的准入率为14.4%。在符合准入条件的人群中，当前吸烟率在Lc65+队列中为58.7%，瑞士健康调查中为60.1%，CoLaus队列中为64.9%。符合准入条件的研究对象往往合并症负担与社会脆弱性更高，包括心血管疾病、代谢综合征、抑郁状态以及较低的受教育程度或收入水平；各数据集间的统计学显著性差异表现不一。

研究结论
本研究针对瑞士沃州人群的分析显示，约六分之一的成年人符合肺癌筛查准入标准。研究结果凸显了将早筛与戒烟、健康促进以及公平获取医疗服务相结合的必要性。