Audiological test results.

Objective
The study aimed to evaluate the effect of systemic cisplatin administration on off-frequency masking audiometry.
Methods
Among 26 patients receiving systemic cisplatin, 48 ears were included in the analysis. All patients underwent pure-tone audiometry with ipsilateral narrow-band masking noise (off-frequency masking audiometry). In the off-frequency masking audiometry, 70 dBHL band-pass noise (center frequency 1000 Hz, 1/3 octave bandwidth) was administered to the tested ear. The acquired thresholds were compared to those of standard pure-tone audiometry, and threshold elevations greater than 10 dB were regarded as significant. The number of patients showing abnormal threshold elevation was compared between before and after the cisplatin administration.
Results
Before cisplatin administration, 91.7, 93.8, 97.9, and 93.8% of ears showed normal off-frequency masking audiometry outcomes at 125, 250, 6000, and 8000 Hz, respectively. After cisplatin administration, a higher number of patients showed abnormal off-frequency masking audiometry outcomes. This change was more prominent with increasing doses of cisplatin. After the cisplatin administration of 100∼200 mg/m2, the prevalence of patients with normal off-frequency masking audiometry outcomes was 77.3, 70.5, 90.9, and 88.6% at 125, 250, 6000, and 8000 Hz, respectively. At 250 Hz, the change was statistically significant (p = 0.01, chi-squared test).

研究目的：本研究旨在评估全身给予顺铂（cisplatin）对离频掩蔽听阈测试（off-frequency masking audiometry）的影响。
研究方法：本研究纳入26例接受全身顺铂治疗的患者，共计48耳纳入分析。所有受试者均接受同侧窄带掩蔽噪声下的纯音听阈测试（pure-tone audiometry），即离频掩蔽听阈测试：于受试耳给予70 dBHL的带通噪声（中心频率1000 Hz，1/3倍频程带宽）。将测得的听阈与标准纯音听阈测试结果进行对比，将听阈升高幅度超过10 dB的情况判定为异常。对比顺铂给药前后出现异常听阈升高的患者例数。
研究结果：顺铂给药前，在125 Hz、250 Hz、6000 Hz及8000 Hz频率下，分别有91.7%、93.8%、97.9%及93.8%的受试耳表现为正常的离频掩蔽听阈测试结果。顺铂给药后，出现异常离频掩蔽听阈测试结果的患者数量有所增加，且该变化随顺铂给药剂量升高更为显著。当顺铂给药剂量为100~200 mg/m²时，各频率下正常离频掩蔽听阈测试结果的受试耳占比分别为：125 Hz时77.3%、250 Hz时70.5%、6000 Hz时90.9%、8000 Hz时88.6%。其中250 Hz频率下的变化具有统计学显著性（chi-squared检验，p=0.01）。