Dataset related to the article "High sensitivity C-reactive protein and acute kidney injury in patients wit acute myocardial infarction: a prospective observational study"

This record contains raw data related to the article "High sensitivity C-reactive protein and acute kidney injury in patients wit acute myocardial infarction: a prospective observational study" <strong>Abstract:</strong> Background. Accumulating evidence suggests that inflammation plays a key role in acute<br> kidney injury (AKI) pathogenesis. We explored the relationship between high-sensitivity C-reactive<br> protein (hs-CRP) and AKI in acute myocardial infarction (AMI). Methods. We prospectively included<br> 2,063 AMI patients in whom hs-CRP was measured at admission. AKI incidence and a clinical<br> composite of in-hospital death, cardiogenic shock, and acute pulmonary edema were the study<br> endpoints. Results. Two-hundred-thirty-four (11%) patients developed AKI. hs-CRP levels were<br> higher in AKI patients (45 87 vs. 16 41 mg/L; p &lt; 0.0001). The incidence and severity of AKI, as well<br> as the rate of the composite endpoint, increased in parallel with hs-CRP quartiles (p for trend &lt;0.0001<br> for all comparisons). A significant correlation was found between hs-CRP and the maximal increase<br> of serum creatinine (R = 0.23; p &lt; 0.0001). The AUC of hs-CRP for AKI prediction was 0.69 (p &lt; 0.001).<br> At reclassification analysis, addition of hs-CRP allowed to properly reclassify 14% of patients when<br> added to creatinine and 8% of patients when added to a clinical model. Conclusions. In AMI,<br> admission hs-CRP is closely associated with AKI development and severity, and with in-hospital<br> outcomes. Future research should focus on whether prophylactic renal strategies in patients with<br> high hs-CRP might prevent AKI and improve outcome.本数据集收录与论文《急性心肌梗死患者高敏C反应蛋白与急性肾损伤：一项前瞻性观察研究》相关的原始研究数据。<strong>摘要：</strong> 背景：越来越多的证据表明，炎症在急性肾损伤（acute kidney injury, AKI）的发病机制中发挥关键作用。本研究旨在探讨急性心肌梗死（acute myocardial infarction, AMI）患者的高敏C反应蛋白（high-sensitivity C-reactive protein, hs-CRP）与AKI之间的关联。方法：本研究前瞻性纳入2063例急性心肌梗死患者，所有患者均于入院时检测hs-CRP水平。本研究的研究终点为AKI发生率，以及院内死亡、心源性休克与急性肺水肿的复合临床结局。结果：共计234例（11%）患者发生AKI。AKI患者的hs-CRP水平显著更高（45.87 vs 16.41 mg/L；p<0.0001）。AKI的发生率、严重程度以及复合终点事件的发生率均随hs-CRP四分位数分组升高而呈递增趋势（所有趋势检验p值均<0.0001）。hs-CRP与血清肌酐的最大升高值呈显著正相关（R=0.23；p<0.0001）。hs-CRP用于预测AKI的受试者工作特征曲线下面积（Area Under the Receiver Operating Characteristic Curve, AUC）为0.69（p<0.001）。重分类分析显示，在肌酐指标基础上加入hs-CRP可正确重分类14%的患者，而在临床模型基础上加入hs-CRP则可正确重分类8%的患者。结论：在急性心肌梗死患者中，入院时的hs-CRP水平与AKI的发生、严重程度及院内临床结局密切相关。未来的研究应聚焦于高hs-CRP水平患者的预防性肾脏干预策略是否能够预防AKI并改善临床结局。