DataSheet1_Hotspots and trends in multiple myeloma bone diseases: A bibliometric visualization analysis.doc

Objective: This study aims to explore the research hotspots and trends of multiple myeloma bone disease in the past 20 years by bibliometric visualization analysis.
Methods: With the Web of Science Core Collection database as the data source, the relevant publications of multiple myeloma bone disease from 2002 to 2021 are retrieved. These data are analyzed using software CiteSpace 5.8.R3 and Scimago Graphica 1.0.24, together with the Online Analysis Platform of Literature Metrology.
Results: A total of 6,168 published research papers, including 4668 articles and 1500 review papers, are included in this study. Generally speaking, annual publications and citations are on the rise, especially in recent 2 years. The majority of these papers are published in the United States, with Mayo Clinic being the greatest contributor. The most productive journal and author are Blood and Terpos E, respectively, while the most frequently co-cited reference, author and journal are Rajkumar et al., 2014, Lancet Oncol, Kyle RA and Blood, respectively. The major research subject categories are oncology and hematology. The “disease diagnosis”, “prognosis evaluation”, “pathogenesis”, “imaging technology” and “targeted therapy” are recent research frontiers. The burst keywords “transplantation”, “progression”, “activation”, “lenalidomide”, “flow cytometry”, “drug resistance”, “management” and “mesenchymal stem cell” reflect the latest research hotspots.
Conclusion: This study reveals the research hotspots and trends of multiple myeloma bone disease through bibliometric visualization analysis, and provides a valuable reference for further research.

研究目的：本研究旨在通过文献计量可视化分析（bibliometric visualization analysis），探究近20年多发性骨髓瘤骨病（multiple myeloma bone disease）的研究热点与发展趋势。
研究方法：本研究以Web of Science核心合集（Web of Science Core Collection）数据库为数据源，检索2002年至2021年间与多发性骨髓瘤骨病相关的学术文献。采用CiteSpace 5.8.R3、Scimago Graphica 1.0.24两款软件，结合文献计量在线分析平台对上述数据开展分析。
研究结果：本研究共纳入6168篇已发表的学术论文，其中包括4668篇研究论文与1500篇综述论文。整体而言，年度发文量与被引量均呈上升趋势，近2年尤为显著。发文量最高的国家为美国，梅奥诊所（Mayo Clinic）是贡献度最高的研究机构。发文量最多的期刊与作者分别为《Blood》与Terpos E；而被引频次最高的合著文献、作者与期刊分别为Rajkumar等人2014年发表于《Lancet Oncol》的研究、Kyle RA与《Blood》。主要研究学科类别为肿瘤学与血液学。“疾病诊断”“预后评估”“发病机制”“影像技术”与“靶向治疗”为当前最新的研究前沿。突现关键词“移植（transplantation）”“疾病进展（progression）”“活化（activation）”“来那度胺（lenalidomide）”“流式细胞术（flow cytometry）”“耐药性（drug resistance）”“临床管理（management）”与“间充质干细胞（mesenchymal stem cell）”反映了最新的研究热点。
研究结论：本研究通过文献计量可视化分析，揭示了多发性骨髓瘤骨病的研究热点与发展趋势，可为后续相关研究提供具有参考价值的借鉴。