Impact of late radiation effects on cancer survivor children: an integrative review

We aimed to identify the late effects of radiation exposure in pediatric cancer survivors. An integrated literature review was performed in the databases MEDLINE and LILACS and SciELO. Included were articles in Portuguese and English, published over the past 10 years, using the following keywords: “neoplasias/neoplasms” AND “radioterapia/radiotherapy” AND “radiação/radiation”. After analysis, 14 articles - published in nine well-known journals - met the inclusion criteria. The publications were divided into two categories: “Late endocrine effects” and “Late non-endocrine effects”. Considering the increased survival rates in children who had cancer, the impact of late effects of exposure to radiation during radiological examinations for diagnosis and treatment was analyzed. Childhood cancer survivors were exposed to several late effects and should be early and regularly followed up, even when exposed to low radiation doses.

本研究旨在明确儿科癌症幸存者的辐射暴露远期效应。本研究在MEDLINE、LILACS及SciELO数据库中开展综合文献综述，纳入标准为：以葡萄牙语或英语发表、近10年内刊载且使用以下检索词的文献："neoplasias/neoplasms（肿瘤）" AND "radioterapia/radiotherapy（放射治疗）" AND "radiação/radiation（辐射）"。经筛选分析后，共计14篇发表于9家知名期刊的文献符合纳入标准。将纳入文献分为两类："内分泌远期效应"与"非内分泌远期效应"。鉴于儿童癌症患者的生存率持续提升，本研究针对诊断与治疗过程中放射检查带来的辐射暴露远期效应的影响展开分析。儿科癌症幸存者可能面临多种远期效应，即便仅接受低剂量辐射暴露，也应尽早且定期接受随访监测。