Pharmacoepigenomic impact of Anti-hypertensive drugs on DNA methylation: A genomewide methylation study

Supplementary Materials: The following supporting information can be downloaded at: www.mdpi.com/xxx/s1, Figure S1: Methodology. Figure S2: Up and Down bar plot representing the DMPs that are being discussed in the paper. Table S1: List of primer and the primer sequence of epigenetic genes in the mRNA expression analysis. Table S2: Effect of antihypertensive drugs at varying concentration and duration on the mRNA expression of DNA methyltransferases and DNA demethylases. Table S3: List of common probes and genes that are differentially methylated after AMLO (6-hours and 24-hours) treatment and after ENALA (6-hours and 24-hours) treatment. Table S4: List of probes and genes that were reverted upon duration after treatment. Table S5: List of Gene ontology terms, Fold enrichment, FDR value, Count and Class of each treatment.补充材料：以下支持性信息可通过以下链接下载：www.mdpi.com/xxx/s1。 图S1：研究方法。 图S2：用于展示本文所讨论的差异甲基化位点（Differentially Methylated Positions, DMPs）的上调与下调柱状图。 表S1：mRNA表达分析中表观遗传基因的引物及其引物序列列表。 表S2：不同浓度与作用时长的降压药物对DNA甲基转移酶与DNA去甲基化酶mRNA表达的影响。 表S3：经氨氯地平（AMLO，6小时与24小时）及依那普利（ENALA，6小时与24小时）处理后出现差异甲基化的共有探针与基因列表。 表S4：随处理时长变化而出现甲基化状态逆转的探针与基因列表。 表S5：各处理组的基因本体（Gene Ontology, GO）条目、富集倍数、错误发现率（FDR）值、计数及类别列表。