The Institute of Structural and Molecular Biology (ISMB) application for beam time, comprising groups from Birkbeck College, UCL and the Que

The ISMB spans Birkbeck and UCL with researchers in the core Departments at Birkbeck Biological Sciences and several UCL Research Departments. Research groups from Queen Mary University of London (QMUL) and Kingston University (KU) are joint co-applicants as they have strong links and collaborations with groups from ISMB. All groups share common interests in disciplines including structural, chemical, molecular and cell biology; using multidisciplinary and multiscalar approaches. ISMB, UCL, QMUL and KU investigators, ranging from early-career research fellows to internationally-established senior academics, apply X-ray crystallography carried out mainly at our Wellcome funded facility at Birkbeck, as an essential method enabling: i) description of the atomic-level mechanistic details of macromolecules and macromolecular machines, and ii) structure-based drug discovery, while iii) complementing and supporting cryo-electron microscopy (cryo-EM) projects.

结构与分子生物学研究机构（ISMB）的研究网络覆盖伯克贝克学院与伦敦大学学院（UCL），其研究人员来自伯克贝克生物科学学院的核心院系，以及伦敦大学学院的多个研究院系。伦敦大学玛丽女王学院（Queen Mary University of London, QMUL）与金斯顿大学（Kingston University, KU）的研究团队作为联合共同申请人加入本合作，因其与ISMB下属研究团队联系紧密且合作深厚。所有参与团队的研究兴趣均涵盖结构生物学、化学、分子生物学与细胞生物学等学科，并采用多学科、多尺度的研究方法开展工作。ISMB、UCL、QMUL与KU的研究人员梯队覆盖全面，从早期职业研究学者到国际知名资深学者均有参与。他们主要依托伯克贝克分校由惠康基金会资助的实验设施开展X射线晶体学研究，该方法是实现以下核心目标的关键技术手段：i）解析大分子与分子机器的原子级作用机制细节；ii）开展基于结构的药物研发；同时iii）作为补充技术支撑冷冻电子显微镜（cryo-electron microscopy, cryo-EM）相关研究项目。