Molecular Prognosis of Cardiogenic Shock Patients under Extracorporeal Membrane Oxygenation. Homo sapiens

Prognosis for cardiogenic shock patients under ECMO was our study goal. Success defined as survived more than 7 days after ECMO installation and failure died or had multiple organ failure in 7 days. Total 34 cases were enrolled, 17 success and 17 failure. Peripheral blood mononuclear cells collected at ECMO installation were used analyzed. Overall design: Analysis of the cardiogenic shock patients at extracorporeal membrane oxygenation treatment by genome-wide expression and methylation. Transcriptomic profiling and DNA methylation between successful and failure groups were analyzed. This submission represents the transcriptome data.

本研究旨在探究接受体外膜肺氧合（extracorporeal membrane oxygenation, ECMO）治疗的心源性休克（cardiogenic shock）患者的预后结局。将患者在体外膜肺氧合置管后存活超过7天定义为预后成功，7天内死亡或出现多器官功能衰竭则定义为预后失败。本研究共纳入34例受试者，其中预后成功组与预后失败组各17例。采集受试者接受体外膜肺氧合置管时的外周血单个核细胞（peripheral blood mononuclear cells, PBMC）进行分析。整体实验设计：采用全基因组表达与甲基化分析手段，对接受体外膜肺氧合治疗的心源性休克患者展开研究。对预后成功组与失败组的转录组谱及DNA甲基化水平进行对比分析。本次提交的数据为转录组数据。