Longitudinal Study of Vaginal Flora

This prospective observational study aims to advance our knowledge of the natural history and abnormal alteration in vaginal microbial flora, and to identify risk factors that are associated with these changes. A total of 5500 healthy, non-pregnant women of reproductive age will be enrolled and followed up in Birmingham, Alabama, for one year (baseline visit plus once every three months afterwards, totaling 5 visits). Detailed information on sociodemographic status, medical history, hygiene practice, sexual behavior and psychosocial stress will be collected through in-person interviews. Routine gynecological and dental examinations will be carried out during the study visits. Samples of vaginal secretion and blood will be collected. Laboratory tests to quantify vaginal microbial flora... (for more see dbGaP study page.)

本项前瞻性观察性研究旨在深化对阴道微生物群（vaginal microbial flora）自然演变过程及异常改变的认知，并识别与此类变化相关的危险因素。研究将在美国阿拉巴马州伯明翰市招募共计5500名健康非妊娠育龄女性，开展为期一年的随访，包含1次基线访视与后续每3个月1次的访视，总计5次访视。研究将通过面对面访谈收集受试者的社会人口学特征、病史、卫生习惯、性行为及心理社会压力等详细信息；在每次研究访视期间，还将开展常规妇科与牙科检查，并采集阴道分泌物与血液样本，用于阴道微生物群定量相关的实验室检测……（更多详情请参见dbGaP研究页面）