PCOS

Polycystic ovarian syndrome (PCOS) is a chronic disorder with a prevalence of 10% in women worldwide and its etiology still remains poorly understood. Insulin resistance is believed to be a main pathogenic factor involved in metabolic disturbances of PCOS. Butyrylcholinesterase (BuChE) has been shown to be linked with insulin resistance, type 2 diabetes and metabolic syndrome. Reduced activity of paraoxonase 1 (PON1) has also been reported in susceptibility to insulin resistance and the other metabolic diseases.
It was to evaluate the enzymatic activity of BuChE, PON1 and their association with insulin resistance in PCOS women.
In this case-control study, 56 PCOS women as the case group and 62 non-PCOS women as the control group were enrolled. Menstrual status, metabolic parameters such as fasting blood insulin (FINS), fasting blood sugar (FBS), homeostatic model assessment of insulin resistance (HOMA-IR), body mass index (BMI) was measured. Enzymatic activity of BuChE and PON1 was also measured.
PCOS women had significantly higher menstrual irregularity (P=0.001), FINS (P=0.018), HOMA-IR (P=0.034) and BuChE activity (P=0.004) and lower PON1 activity (P = 0.006) than control. In PCOS women, BuChE was significantly correlated with BMI. In Insulin resistant women, BuChE activity was significantly higher in PCOS than control (P=0.012). No significant relationship was found between BuChE and PON1 activity in PCOS patients (P = 0.07).
These results indicate that higher BuChE and lower PON1 activity are associated with pathogenesis of PCOS and insulin resistance could be a link for this connection.

多囊卵巢综合征（Polycystic ovarian syndrome, PCOS）是一种慢性疾病，全球女性患病率达10%，但其病因至今仍未完全阐明。目前认为胰岛素抵抗是参与多囊卵巢综合征代谢紊乱的主要致病因素之一。已有研究表明，丁酰胆碱酯酶（Butyrylcholinesterase, BuChE）与胰岛素抵抗、2型糖尿病及代谢综合征密切相关；对氧磷酶1（paraoxonase 1, PON1）活性降低也被报道与胰岛素抵抗及其他代谢疾病的易感性相关。

本研究旨在探讨多囊卵巢综合征女性体内BuChE、PON1的酶活性，及其与胰岛素抵抗的关联。

本病例对照研究共纳入56例多囊卵巢综合征女性作为病例组，62例非多囊卵巢综合征女性作为对照组。收集受试者的月经状态数据，并检测代谢相关指标，包括空腹胰岛素（fasting blood insulin, FINS）、空腹血糖（fasting blood sugar, FBS）、胰岛素抵抗稳态模型评估指数（homeostatic model assessment of insulin resistance, HOMA-IR）以及身体质量指数（body mass index, BMI），同时测定BuChE与PON1的酶活性。

与对照组相比，多囊卵巢综合征女性的月经紊乱发生率（P=0.001）、空腹胰岛素水平（P=0.018）、HOMA-IR指数（P=0.034）及BuChE活性（P=0.004）均显著升高，而PON1活性则显著降低（P=0.006）。在多囊卵巢综合征女性中，BuChE活性与BMI呈显著正相关；在胰岛素抵抗人群中，多囊卵巢综合征女性的BuChE活性显著高于对照组（P=0.012）。多囊卵巢综合征患者体内BuChE与PON1活性未发现显著相关性（P=0.07）。

上述结果表明，升高的BuChE活性与降低的PON1活性与多囊卵巢综合征的发病机制相关，而胰岛素抵抗可能是二者关联的潜在纽带。