Gene expression set for inflammatory mediators in blood from patients with severe SARS-CoV-2 infection

This study examines natural killer (NK) cells from severe COVID-19 patients and a healthy group, analyzing metabolic (SIRT1, AMPKA, HIF1A, GLUT1) and inflammatory (NFKB1, NFKB1A, IFNG, SOCS1) related gene expression, as well as functional markers on NK cells. Also, the expression of these genes was evaluated across different clinical contexts related to outcomes in severe COVID-19 patients. NK cells from severe COVID-19 patients showed a dysregulated metabolic gene expression associated with adverse outcomes, highlighting the involvement of metabolism in COVID-19 severity.

本研究针对重症新型冠状病毒肺炎（COVID-19）患者与健康对照组的自然杀伤细胞（natural killer, NK）展开分析，检测了代谢相关（SIRT1、AMPKA、HIF1A、GLUT1）与炎症相关（NFKB1、NFKB1A、IFNG、SOCS1）基因的表达水平，并分析了NK细胞表面的功能标志物。此外，本研究还针对与重症COVID-19患者临床转归相关的不同临床场景，评估了上述基因的表达情况。研究发现，重症COVID-19患者体内的NK细胞存在代谢基因表达失调现象，且该失调与不良临床转归相关，凸显了代谢过程在COVID-19重症化进程中的作用。