Scaling of gene expression with liver cell size in vivo. Scaling of gene expression with liver cell size in vivo

A partially hepatectomized mouse liver with a liver-specific conditional Cdk1 knock-out genotype grows back to the normal size in the absence of cell divisions resulting in highly enlarged nuclear and cell size. This experiment analyses gene expression in four sets of mouse livers all with different nuclear sizes: controls without hepatectomy, controls with hepatectomy, Cdk1 null without hepatectomy and Cdk1 null with hepatectomy.

携带肝特异性条件性细胞周期蛋白依赖性激酶1(Cdk1)敲除基因型的部分肝切除小鼠肝脏，可在未发生细胞分裂的情况下恢复至正常体积，最终形成核体积与细胞体积均显著增大的肝脏。本实验针对四组核体积各不相同的小鼠肝脏开展基因表达分析，四组分别为：未行肝切除术的对照组、行肝切除术的对照组、未行肝切除术的Cdk1敲除组，以及行肝切除术的Cdk1敲除组。