Additional file 3 of Mendelian randomization study of inflammatory bowel disease and bone mineral density

Additional file 3: Figure S1. Funnel plots for MR analyses of the causal effect of IBD on BMDs in initial practice (A) TB-BMD (B) FN-BMD (C) LS-BMD (D) FA-BMD. Figure S2. Plots of “leave-one-out” analyses for MR analyses of the causal effect of IBD on BMDs in initial practice (A) TB-BMD (B) FN-BMD (C) LS-BMD (D) FA-BMD. Figure S3. Funnel plots for MR analyses of the causal effect of IBD on BMDs in replicative practice (A) TB-BMD (B) FN-BMD (C) LS-BMD (D) FA-BMD. Figure S4. Plots of “leave-one-out” analyses for MR analyses of the causal effect of IBD on BMDs in replicative practice (A) TB-BMD (B) FN-BMD (C) LS-BMD (D) FA-BMD. Figure S5. Funnel plots for MR analyses of the causal effect of UC on BMDs in initial practice (A) TB-BMD (B) FN-BMD (C) LS-BMD (D) FA-BMD. Figure S6. Plots of “leave-one-out” analyses for MR analyses of the causal effect of UC on BMDs in initial practice (A) TB-BMD (B) FN-BMD (C) LS-BMD (D) FA-BMD. Figure S7. Funnel plots for MR analyses of the causal effect of UC on BMDs in replicative practice (A) TB-BMD (B) FN-BMD (C) LS-BMD (D) FA-BMD. Figure S8. Plots of “leave-one-out” analyses for MR analyses of the causal effect of UC on BMDs in replicative practice (A) TB-BMD (B) FN-BMD (C) LS-BMD (D) FA-BMD. Figure S9. Funnel plots for MR analyses of the causal effect of CD on BMDs in initial practice (A) TB-BMD (B) FN-BMD (C) LS-BMD (D) FA-BMD. Figure S10. Plots of “leave-one-out” analyses for MR analyses of the causal effect of CD on BMDs in initial practice (A) TB-BMD (B) FN-BMD (C) LS-BMD (D) FA-BMD. Figure S11. Funnel plots for MR analyses of the causal effect of CD on BMDs in replicative practice (A) TB-BMD (B) FN-BMD (C) LS-BMD (D) FA-BMD. Figure S12. Plots of “leave-one-out” analyses for MR analyses of the causal effect of CD on BMDs in replicative practice (A) TB-BMD (B) FN-BMD (C) LS-BMD (D) FA-BMD.补充材料3：图S1。针对初始队列中炎症性肠病（Inflammatory Bowel Disease, IBD）对骨密度（Bone Mineral Density, BMD）因果效应的孟德尔随机化（Mendelian Randomization, MR）分析漏斗图：(A) 全身骨密度（TB-BMD）；(B) 股骨颈骨密度（FN-BMD）；(C) 腰椎骨密度（LS-BMD）；(D) 前臂骨密度（FA-BMD）。图S2。针对初始队列中炎症性肠病对骨密度因果效应的孟德尔随机化分析留一法分析图：(A) 全身骨密度（TB-BMD）；(B) 股骨颈骨密度（FN-BMD）；(C) 腰椎骨密度（LS-BMD）；(D) 前臂骨密度（FA-BMD）。图S3。针对重复验证队列中炎症性肠病对骨密度因果效应的孟德尔随机化分析漏斗图：(A) 全身骨密度（TB-BMD）；(B) 股骨颈骨密度（FN-BMD）；(C) 腰椎骨密度（LS-BMD）；(D) 前臂骨密度（FA-BMD）。图S4。针对重复验证队列中炎症性肠病对骨密度因果效应的孟德尔随机化分析留一法分析图：(A) 全身骨密度（TB-BMD）；(B) 股骨颈骨密度（FN-BMD）；(C) 腰椎骨密度（LS-BMD）；(D) 前臂骨密度（FA-BMD）。图S5。针对初始队列中溃疡性结肠炎（Ulcerative Colitis, UC）对骨密度因果效应的孟德尔随机化分析漏斗图：(A) 全身骨密度（TB-BMD）；(B) 股骨颈骨密度（FN-BMD）；(C) 腰椎骨密度（LS-BMD）；(D) 前臂骨密度（FA-BMD）。图S6。针对初始队列中溃疡性结肠炎对骨密度因果效应的孟德尔随机化分析留一法分析图：(A) 全身骨密度（TB-BMD）；(B) 股骨颈骨密度（FN-BMD）；(C) 腰椎骨密度（LS-BMD）；(D) 前臂骨密度（FA-BMD）。图S7。针对重复验证队列中溃疡性结肠炎对骨密度因果效应的孟德尔随机化分析漏斗图：(A) 全身骨密度（TB-BMD）；(B) 股骨颈骨密度（FN-BMD）；(C) 腰椎骨密度（LS-BMD）；(D) 前臂骨密度（FA-BMD）。图S8。针对重复验证队列中溃疡性结肠炎对骨密度因果效应的孟德尔随机化分析留一法分析图：(A) 全身骨密度（TB-BMD）；(B) 股骨颈骨密度（FN-BMD）；(C) 腰椎骨密度（LS-BMD）；(D) 前臂骨密度（FA-BMD）。图S9。针对初始队列中克罗恩病（Crohn's Disease, CD）对骨密度因果效应的孟德尔随机化分析漏斗图：(A) 全身骨密度（TB-BMD）；(B) 股骨颈骨密度（FN-BMD）；(C) 腰椎骨密度（LS-BMD）；(D) 前臂骨密度（FA-BMD）。图S10。针对初始队列中克罗恩病对骨密度因果效应的孟德尔随机化分析留一法分析图：(A) 全身骨密度（TB-BMD）；(B) 股骨颈骨密度（FN-BMD）；(C) 腰椎骨密度（LS-BMD）；(D) 前臂骨密度（FA-BMD）。图S11。针对重复验证队列中克罗恩病对骨密度因果效应的孟德尔随机化分析漏斗图：(A) 全身骨密度（TB-BMD）；(B) 股骨颈骨密度（FN-BMD）；(C) 腰椎骨密度（LS-BMD）；(D) 前臂骨密度（FA-BMD）。图S12。针对重复验证队列中克罗恩病对骨密度因果效应的孟德尔随机化分析留一法分析图：(A) 全身骨密度（TB-BMD）；(B) 股骨颈骨密度（FN-BMD）；(C) 腰椎骨密度（LS-BMD）；(D) 前臂骨密度（FA-BMD）。