A secondary-structure model for the self-cleaving region of Neurospora VS RNA.
收藏PubMed Central1995-05-09 更新2026-05-02 收录
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https://pmc.ncbi.nlm.nih.gov/articles/PMC42009/
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资源简介：
Neurospora VS RNA performs an RNA-mediated self-cleavage reaction whose products contain 2',3'-cyclic phosphate and 5'-hydroxyl termini. This reaction is similar to those of hammerhead, hairpin, and hepatitis delta virus ribozymes; however, VS RNA is not similar in sequence to these other self-cleaving motifs. Here we propose a model for the secondary structure of the self-cleaving region of VS RNA, supported by site-directed mutagenesis and chemical modification structure probing data. The secondary structure of VS RNA is distinct from those of the other naturally occurring RNA self-cleaving domains. In addition to a unique secondary structure, several Mg-dependent interactions occur during the folding of VS RNA into its active tertiary conformation. IMAGES:
提供机构：
National Academy of Sciences
创建时间：
1995-05-09
