Sirt6

ENCODES a protein that exhibits protein lysine deacetylase activity; chromatin binding (ortholog); chromatin DNA binding (ortholog); INVOLVED IN cellular response to angiotensin; cellular response to endothelin; cellular response to hydrogen peroxide; PARTICIPATES IN histone modification pathway; Sirtuin mediated pathway; ASSOCIATED WITH Cardiomegaly; metabolic dysfunction-associated steatotic liver disease; obesity; FOUND IN chromatin (ortholog); chromosome, subtelomeric region (ortholog); endoplasmic reticulum (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; bisphenol A

编码一种展现出蛋白赖氨酸脱乙酰化活性的蛋白质；参与染色质结合（同源）；参与染色质DNA结合（同源）；参与细胞对血管紧张素、内皮素、过氧化氢的响应；参与组蛋白修饰途径；参与Sirtuin介导的途径；与心肥大、代谢功能障碍相关脂肪性肝病、肥胖相关；存在于染色质（同源）、染色体亚端粒区（同源）、内质网（同源）中；与2,3,7,8-四氯二苯并-对-二恶英、2,4-二硝基甲苯、双酚A相互作用。