Rewiring of the promoter-enhancer interactome and regulatory landscape in glioblastoma orchestrates gene expression underlying the neurogliomal synaptic communication [Cut&Run]

Glioblastoma (GBM) is the most aggressive of all primary brain tumours. Here, we perform a multi-omics approach to map the promoter-enhancer interactome and the regulatory landscape of glioblastoma, including RNA-seq, ChIP-seq of histone marks, HiChIP and ATAC-seq. CUT and RUN

胶质母细胞瘤（Glioblastoma, GBM）是所有原发性脑肿瘤中侵袭性最强的类型。本研究采用多组学研究策略，绘制胶质母细胞瘤的启动子-增强子互作组及其调控图谱，涵盖RNA测序（RNA-seq）、组蛋白修饰染色质免疫共沉淀测序（ChIP-seq）、HiChIP以及转座酶可及性测序（ATAC-seq）与CUT&RUN技术。