Expression data from tibialis anterior muscle of rats fed different fatty acid enriched diets

Omega-3 and omega-6 polyunsaturated fatty acids (PUFA) have important signalling roles in the body. The goal of this study was to investigate the impact of linoleic acid (LA, omega-6) and alpha-linolenic (ALA, omega-3) on global skeletal muscle gene expression. We were also interested to study the impact of these fatty acids on myokine expression. To differentiate the roles of essential dietary PUFA on skeletal muscle function, we fed male rats a control diet (AIN-93G) or diets containing 10% safflower oil or flaxseed oil. Skeletal muscle gene expression was investigated by microrray. Group comparison of tibialis anterior muscle from rats fed different fatty acid enriched diets.

ω-3与ω-6多不饱和脂肪酸（polyunsaturated fatty acids, PUFA）在机体内具有重要的信号调控功能。本研究旨在探究亚油酸（linoleic acid, LA，ω-6）与α-亚麻酸（alpha-linolenic, ALA，ω-3）对全基因组骨骼肌基因表达的影响，同时关注上述脂肪酸对肌因子表达的调控作用。为厘清膳食必需多不饱和脂肪酸在骨骼肌功能中的差异化作用，我们为雄性大鼠饲喂对照饲料（AIN-93G），或添加10%红花籽油、10%亚麻籽油的实验日粮。本研究通过微阵列（microarray）技术检测骨骼肌基因表达水平，并对饲喂不同脂肪酸富集日粮的大鼠胫前肌样本开展组间比较分析。