Infection of bats and cell cultures with Marburg, Ebola and Rabies viruses. Infection of bats and cell cultures with Marburg, Ebola and Rabies viruses

The response of bats to filoviral infections was studied to understand how they avoid getting sick Overall design: Bat cell lines, as well as live bats were infected with Marburg, Ebola and Rabies viruses to understand the innate response of bats and understand how they differ from the human response. Grant ID: HDTRA11610033 Grant title: Comparative Immunology of Rousettus aegyptiacus Reservoir with Filovirus Grantee: Christopher Basler Funding source: Defense Threat Reduction Agency (DTRA)

本研究针对蝙蝠应对丝状病毒（filovirus）感染的免疫应答展开探究，以阐明其为何不会因感染而致病。
整体实验方案：分别以马尔堡（Marburg）、埃博拉（Ebola）及狂犬（Rabies）病毒感染蝙蝠细胞系与活体蝙蝠，旨在解析蝙蝠的固有免疫应答机制，并明确其与人类免疫应答的差异。
资助项目编号：HDTRA11610033
项目名称：丝状病毒自然宿主埃及果蝠（Rousettus aegyptiacus）的比较免疫学研究
项目负责人：Christopher Basler
资助方：国防威胁降低局（Defense Threat Reduction Agency, DTRA）