Campylobacter jejuni RM1246 Sequencing & Assembly. Campylobacter jejuni strain:RM1246-ERRC

Campylobacter jejuni strain RM1246-ERRC was a kind gift from the laboratory collection of Dr. Robert Mandrell (USDA-WRRC, Albany, CA) and previously labeled as RM1246. This strain originally designated 92A3120 was a clinical isolate derived from a case of human disease by the California State Public Health Lab in Berkeley California (Sharon L. Abbott) and exhibited Penner serotype HS:7. This strain has been utilized in multiple antimicrobial challenge studies. In a recent study the strain exhibited resistance to quaternary ammonium compounds (QACs) in excess of other Campylobacter jejuni strains used in the same study. The genetic material of the strain consists of a chromosome of 1.66 MB and a single plasmid of 45.20 KB in size. The chromosome of the strain possess four separate genes that code for membrane transporters of cationic drugs belonging to the SMR family of proteins. Orthologues of these genes in other species have been shown to be capable of the efflux of QACs.

空肠弯曲杆菌（Campylobacter jejuni）菌株RM1246-ERRC由罗伯特·曼德雷尔博士（美国农业部西部区域研究中心，USDA-WRRC，加利福尼亚州奥尔巴尼）的实验室馆藏惠赠，此前该菌株的标注名称为RM1246。该菌株最初被命名为92A3120，是由加利福尼亚州伯克利市的加利福尼亚州公共卫生实验室（Sharon L. Abbott）从一例人类病例中分离得到的临床分离株，其Penner血清型为HS:7。该菌株已被应用于多项抗菌药物挑战研究。在近期的一项研究中，该菌株对季铵盐类化合物（quaternary ammonium compounds, QACs）的耐药性显著高于同研究中使用的其他空肠弯曲杆菌菌株。该菌株的遗传物质包含一条1.66 Mb的染色体以及一条大小为45.20 Kb的单一质粒。该菌株的染色体上携带四个独立的基因，这些基因编码属于小多重耐药（Small Multidrug Resistance, SMR）蛋白家族的阳离子药物膜转运蛋白。其他物种中这些基因的同源基因已被证实可介导季铵盐类化合物的外排转运。