Targeting EZH2 increases the vulnerability of triple-negative breast cancer

We hypothesize that knockdown or inhibition of the EZH2 results in decreased proliferation and tumorigenic potential of TNBC breast cancer cells Overall design: Examination of gene expression in three TNBC breast cancer cell lines following knockdown of EZH2 or chemical inhibition of EZH2 activity

我们提出如下科学假说：敲低（knockdown）或抑制EZH2，可降低三阴性乳腺癌（triple-negative breast cancer, TNBC）细胞的增殖能力与致瘤潜能。整体实验设计：检测三种三阴性乳腺癌细胞系在EZH2被敲低或其活性经化学抑制后的基因表达水平。