Women's lifestyle and health (WLH)

Oral contraceptives, use of hormone replacement therapy, dietary habits and other lifestyle factors affect the risk for cancer, cardiovascular diseases and other chronic diseases in young women. The overall aim of Women's lifestyle and health cohort is to examine lifestyle factors and health outcomes such as cancer, cardiovascular diseases and some chronic diseases. Starting in 1991, a comprehensive questionnaire was mailed to 96,000 Swedish women aged 29-49 years. Approximately 50,000 completed questionnaires were returned providing detailed information on a wide range of lifestyle factors with a focus on oral contraceptive use, diet, UV light exposure, and reproductive factors. This study is strictly coordinated with a similar study among 60,000 young women in Norway; apart from the dietary component, the questionnaires are identical and joint analyses have been conducted. In 2003, a second questionnaire was sent to all women to update information on lifestyle, and hormonal factors as well as to assess mental health. Currently analysis is ongoing for several lifestyle factors and cancers of the breast, ovarium, endometrial, colorectal, skin, skin melanoma, lymphomas, as well as cardiovascular outcomes (myocardial infarction, haemorragic and ischaemic stroke), psychiatric diseases, sleeping disorders and overall mortality. Several analyses have been performed during the last years on different exposures, such as oral contraceptives, BMI, changes in body size and shape, UV radiation exposure, alcohol consumption, smoking, and risk of different cancer sites and overall mortality. The baseline questionnaire was mailed to 96,000 Swedish women aged 29-49 years, in 1991. The questionnaire was answered by 49,259 women. Participants from the baseline collection were followed up in 2003.口服避孕药（oral contraceptives）、激素替代治疗（hormone replacement therapy）、饮食习惯及其他生活方式因素，均会影响青年女性罹患癌症、心血管疾病及其他慢性疾病的风险。女性生活方式与健康队列（Women's lifestyle and health cohort）的整体研究目标为探究生活方式因素与癌症、心血管疾病及部分慢性疾病等健康结局的关联。 研究始于1991年，团队向96000名年龄介于29至49岁的瑞典女性邮寄了综合性调查问卷，最终回收约50000份有效问卷。问卷收集了涵盖多类生活方式因素的详细信息，重点关注口服避孕药使用情况、饮食状况、紫外线暴露及生殖相关因素。本研究与挪威针对60000名青年女性开展的同类研究保持严格协同：除饮食相关模块外，两份调查问卷完全一致，且已开展联合分析。 2003年，团队向所有纳入女性邮寄了第二份调查问卷，用于更新其生活方式与激素相关因素的信息，并评估精神健康状况。目前，针对多项生活方式因素与乳腺癌、卵巢癌、子宫内膜癌、结直肠癌、皮肤癌、皮肤黑素瘤（skin melanoma）、淋巴瘤，以及心血管结局（心肌梗死、出血性卒中、缺血性卒中）、精神疾病、睡眠障碍和全因死亡率的关联分析正在进行中。 近年以来，研究团队已针对多项暴露因素开展了多组分析，涵盖口服避孕药使用、身体质量指数（BMI）、体型变化、紫外线暴露、饮酒、吸烟，以及不同部位癌症风险与全因死亡率的关联。 1991年，研究团队向96000名29至49岁的瑞典女性邮寄了基线调查问卷，最终有49259名女性完成作答。基线队列的纳入对象已于2003年完成随访。