Global, regional, and national burden and trends of mental disorders in women of childbearing age: a systematic analysis based on the global burden of disease study 2021

This study aims to provide a comprehensive picture of mental disorder burden in women of childbearing age (WCBA), providing scientific evidence for implementing disease prevention and control strategies.
Based on the data from the Global Burden of Disease study 2021, the age-standardized prevalence rates (ASPR) and disability-adjusted life years (DALY) rates (ASDR) of mental disorders in WCBA, along with their temporal trends, age-period-cohort effects and projection of epidemiological trajectory over the next 10 years were comprehensively analyzed.
In 2021, there were an estimated 343.22 million mental disorder cases in WCBA, with a global ASPR of 17573.61 per 100,000 population and ASDR of 2696.58 per 100,000 population worldwide. Anxiety disorders accounted for the highest prevalence proportion (37.49%), while depressive disorders were the leading DALYs contributors (39.91%) in mental disorders. From 1990 to 2021, the global mental disorder burden showed significant upward trends, with ASPR and ASDR rising at annual average percent changes (AAPC) of 0.35 and 0.38 respectively. The deterioration was more pronounced in anxiety disorders (AAPC 0.74 and 0.73), eating disorders (AAPC 0.42 and 0.41) and depressive disorders (AAPC 0.39 and 0.45). The APC analysis indicated that the disease burden gradually increased with age, and the relative risk peaked during the period of 2017–2021. The projections suggest that the global burden of mental disorders will persistently rise from 2022 to 2031 in WCBA. Specifically, the ASPR and ASDR are projected to reach 23872.35 per 100,000 population and 3570.07 per 100,000 population in 2031, respectively.
The global burden of mental disorders is particularly severe in WCBA and still on the rise. Innovative prevention and healthcare strategies are urgently needed to reduce the burden of highly prevalent, rapidly increasing diseases in high-risk areas.

This study fills a research blank by presenting a comprehensive global, regional and national perspective on the burden, trends and prediction of mental disorders in WCBA from 1990 to 2021.
The global burden of mental disorders in WCBA is alarmingly high and continues to rise at an accelerating rate.
Urgent implementation of innovative preventive and healthcare strategies is needed to mitigate the burden, especially for disease subtypes with high prevalence or rapid growth, and for regions identified as being at high risk.

This study fills a research blank by presenting a comprehensive global, regional and national perspective on the burden, trends and prediction of mental disorders in WCBA from 1990 to 2021.
The global burden of mental disorders in WCBA is alarmingly high and continues to rise at an accelerating rate.
Urgent implementation of innovative preventive and healthcare strategies is needed to mitigate the burden, especially for disease subtypes with high prevalence or rapid growth, and for regions identified as being at high risk.

本研究旨在全面呈现育龄女性（women of childbearing age, WCBA）的精神障碍疾病负担现状，为制定疾病防控策略提供科学依据。
基于2021年全球疾病负担研究（Global Burden of Disease study）数据，对育龄女性精神障碍的年龄标化患病率（age-standardized prevalence rates, ASPR）、年龄标化伤残调整生命年率（disability-adjusted life years rate, ASDR）及其时间趋势、年龄-时期-队列效应，以及未来10年的流行病学轨迹预测进行了全面分析。
2021年，全球育龄女性精神障碍患病病例估计达3.4322亿例，全球年龄标化患病率为17573.61/10万人口，年龄标化伤残调整生命年率为2696.58/10万人口。其中，焦虑障碍患病率占比最高（37.49%），而抑郁障碍则是精神障碍伤残调整生命年的首要贡献因素（39.91%）。1990年至2021年，全球精神障碍疾病负担呈显著上升趋势，年龄标化患病率与年龄标化伤残调整生命年率的年均变化百分比（annual average percent changes, AAPC）分别为0.35和0.38。焦虑障碍（年均变化百分比分别为0.74、0.73）、进食障碍（年均变化百分比分别为0.42、0.41）与抑郁障碍（年均变化百分比分别为0.39、0.45）的疾病负担恶化更为显著。年龄-时期-队列分析显示，疾病负担随年龄增长逐渐升高，相对风险在2017-2021年期间达到峰值。预测结果表明，2022年至2031年，全球育龄女性精神障碍疾病负担将持续攀升。至2031年，预计全球育龄女性精神障碍的年龄标化患病率与年龄标化伤残调整生命年率将分别达到23872.35/10万人口与3570.07/10万人口。
育龄女性群体的全球精神障碍疾病负担尤为沉重，且仍处于上升态势。亟需创新防控与医疗策略，以降低高患病率、快速增长疾病在高危地区的疾病负担。

本研究通过呈现1990年至2021年育龄女性精神障碍疾病负担、趋势与预测的全球、区域及国家层面的综合视角，填补了相关研究空白。
全球育龄女性精神障碍疾病负担高企，且仍在以加速的态势持续上升。
亟需实施创新型预防与医疗策略，以减轻疾病负担，尤其针对高患病率或快速增长的疾病亚型，以及被认定为高风险的地区。

本研究通过呈现1990年至2021年育龄女性精神障碍疾病负担、趋势与预测的全球、区域及国家层面的综合视角，填补了相关研究空白。
全球育龄女性精神障碍疾病负担高企，且仍在以加速的态势持续上升。
亟需实施创新型预防与医疗策略，以减轻疾病负担，尤其针对高患病率或快速增长的疾病亚型，以及被认定为高风险的地区。