Expression data from plasma of early-onset acute myocardial infarction patients and health control

CircRNAs are a new class of noncoding RNA and play regulatory roles in a variety of human diseases. However, the clinical significance of circRNAs in early-onset acute myocardial infarction (AMI) remains unknown. Therefore, we sought to explore the expression profile of circRNAs in early-onset AMI. Microarray was used to screen differentially expressed circRNAs between early-onset AMI patients and matched healthy controls. Five early-onset AMI patients younger than 45 years and 5 sex- and age-matched healthy control subjects were enrolled for for RNA extraction and hybridization on Affymetrix microarrays.

环状RNA（circRNAs）是一类新型非编码RNA，可在多种人类疾病中发挥调控作用。然而，环状RNA在早发性急性心肌梗死（early-onset acute myocardial infarction, AMI）中的临床意义仍未明确。为此，本研究旨在探讨早发性AMI患者体内环状RNA的表达谱。本研究采用微阵列芯片（microarray）技术，筛选早发性AMI患者与匹配健康对照之间的差异表达环状RNA。本研究纳入5名年龄小于45岁的早发性AMI患者，以及5名性别、年龄匹配的健康对照受试者，用于RNA提取及Affymetrix微阵列芯片杂交实验。