Factors Associated with Outcomes of Pre-ART HIV Care

In 2015 the World Health Organization (WHO) eliminated CD4 restrictions for initiating antiretroviral therapy (ART) for people living with HIV (PLHIV) in developing countries. However, the success of therapy is also dependent upon additional health and demographic characteristics of HIV patients at the time they enroll in care. This study investigated pre-ART (time between enrollment and initiation of ART) factors associated with transition to therapy. Data was compiled from a review of 195,011 records of ART-naïve adults enrolled in HIV care and treatment facilities supported by AIDSRelief in Kenya and Tanzania. The outcome variable was transition out of pre-ART care by one of 4 mutually exclusive modes: started ART, died before ART initiation, lost to follow-up (LTFU), and transferred to another facility. The following baseline covariates were analyzed for their relevance to the mode of transition: sex, age at enrollment, CD4 count at enrollment, presence of tuberculosis at enrollment, presence of cryptococcal disease at enrollment, presence of other active opportunistic infections, and year of enrollment in care. The dataset includes demographic data and clinical measures.

2015年，世界卫生组织（WHO）取消了对发展中国家居住的艾滋病病毒感染者（PLHIV）在启动抗逆转录病毒治疗（ART）时对CD4计数限制。然而，治疗的成败亦取决于患者在入组治疗时的附加健康状况及人口统计学特征。本研究旨在探讨与ART治疗过渡相关的预ART（从入组到启动ART的时间）因素。数据来自对肯尼亚和坦桑尼亚由AIDSRelief支持的HIV治疗与护理设施中195,011例ART初治成年人的记录回顾。结果变量为通过以下四种互斥方式之一从预ART护理中过渡：开始ART治疗、ART启动前死亡、失访（LTFU）和转至其他设施。对以下基线协变量进行了分析，以评估其与过渡方式的相关性：性别、入组时的年龄、入组时的CD4计数、入组时是否存在结核病、入组时是否存在隐球菌病、是否存在其他活动性机会性感染以及入组护理的年份。该数据集包含人口统计学数据和临床指标。