A health metadata-based management approach for comparative analysis of high-throughput genetic sequences for quantifying antimicrobial resistance reduction in Canadian hog barns (Fecal-piglet1

we describe a comprehensive investigative methodology comparing the effect of the adoption of the RWA approach with non-RWA pig production operations where antibiotics may still be administered on animals as needed. Our experimental approach involves a multi-year longitudinal investigation of pig farming to determine the effects of antibiotic usage on the prevalence of antimicrobial resistance (AMR) and pathogen abundance in the context of the drug exposures recorded in the RWA versus non-RWA scenarios

本研究阐述了一套综合性研究方法，用于对比RWA养殖模式与非RWA养猪生产模式的应用效果，其中非RWA模式下仍可根据养殖需求为生猪施用抗生素。本实验方案采用多年期纵向养猪场研究，旨在基于RWA与非RWA场景下记录的药物暴露情况，探究抗生素使用对抗菌素耐药性（antimicrobial resistance, AMR）流行率及病原体丰度的影响。