Transcriptomes of human monocytes from patients with familial hypercholesterolemia before and after statin treatment

Innate immune memory, also refered to as trained immunity (TRIM) is the phenomenon whereby innate immune cells such as monocytes or macrophages undergo functional reprogramming after exposure to microbial components or metabolites. The cholesterol pathway is also involved in TRIM, and in this study we compared the transcriptomes of patients with hypercholesterolemia before and after statin treatment for 3 months. Monocytes from healthy controls and patients with hypercholestoremia before and after 3 months of Statin treatment

固有免疫记忆（Innate immune memory），又称训练免疫（trained immunity, TRIM），指单核细胞（monocytes）、巨噬细胞（macrophages）等固有免疫细胞在接触微生物组分或代谢物后发生功能重编程的现象。胆固醇代谢通路同样参与训练免疫过程，本研究对高胆固醇血症（hypercholesterolemia）患者接受他汀类药物（statin）治疗3个月前后的转录组（transcriptomes）进行了对比分析。研究样本包括健康对照者的单核细胞，以及高胆固醇血症患者接受3个月他汀类药物治疗前后的单核细胞。