Efficient Domino Approaches to Multifunctionalized Fused Pyrroles and Dibenzo[b,e][1,4]diazepin-1-ones

Efficient domino approaches for the synthesis of multifunctionalized tricyclic fused pyrroles and dibenzo[b,e][1,4]diazepin-1-ones have been established. The reaction pathways were controlled by varying enaminones with different substituted patterns to give a series of new fused pyrroles and dibenzo[b,e][1,4]diazepin-1-ones selectively. The complete anti diastereoselectivity was achieved for the first reaction.本工作建立了用于合成多官能团化三环稠合吡咯与二苯并[b,e][1,4]二氮杂䓬-1-酮的高效多米诺合成策略。通过调控不同取代模式的烯胺酮以控制反应路径，可选择性得到一系列新型稠合吡咯及二苯并[b,e][1,4]二氮杂䓬-1-酮类化合物。首个反应实现了完全的反式非对映选择性。