Properties of currents elicited by 10 µM choline plus 2 µM or 5 µM PNU-120596.

The results of experiments where 10 µM choline plus either 2 µM (top row) or 5 µM PNU-1205096 (bottom row) were applied to ACSF for at least 20 min and step-like current deviations in voltage-clamp or action potentials in current-clamp were recorded and analyzed. Significant differences were observed among the frequencies (p = 0.0001) and net charge (p = 0.0001) of step-like current deviations, but not the mean open time (p>0.67). Significant differences were also observed between the frequencies of action potentials (p&) Note that in the presence of 10 µM choline plus 2 µM PNU-120596, action potentials were observed in only 7 out of 13 CA1 pyramidal neurons.