Physicochemical properties of SPD304, T8 and T23, and determination of their dissociation constant with TNF or RANKL under different assay conditions.

PEG3350 was used as co-solvent in order to enhance inhibitors solubility and thus eliminate the possibility of aggregates formation.聚乙二醇3350（PEG3350）被用作助溶剂，以提升抑制剂的溶解度，进而消除聚集体形成的可能性。