Additional file 4: of Transcriptional profiling of liver in riboflavin-deficient chicken embryos explains impaired lipid utilization, energy depletion, massive hemorrhaging, and delayed feathering

Lists of “Analysis Ready” DE genes (AR-DE genes) assigned by IPA to “Canonical Pathways”. A Microsoft Excel file containing a five worksheets of the top “Canonical Pathways” identified by IPA in riboflavin-rescued and riboflavin deficient chick embryos on embryonic day 15 (e15). Five major canonical pathways identified by IPA among DE genes on embryonic day 15 (e15) were: “EIF2 Signaling, Acute-phase Signaling, LXR-RXR Activation, FXR-RXR Activation, Intrinsic Prothrombin Activation”, and “Blood Clotting” in the “Biological Function Category” of IPA. Each worksheet provides the gene symbol, Entrez gene name, gene expression as log2 ratio (Rf+/Rf-), and Ref-Seq protein ID or Entrez gene ID. (XLSX 27 kb)

本数据集收录经IPA（Ingenuity Pathway Analysis）注释至"经典通路（Canonical Pathways）"的"分析就绪型差异表达基因（Analysis Ready DE genes, AR-DE genes）"列表。该文件为Microsoft Excel格式，包含5个工作表，收录了在胚胎第15天（e15）核黄素拯救组与核黄素缺陷组鸡胚中，IPA鉴定得到的顶级"经典通路"。在e15差异表达基因中，IPA鉴定出的5条主要经典通路分别为：EIF2信号通路、急性期信号通路、肝X受体-维甲酸X受体激活通路（LXR-RXR Activation）、法尼醇X受体-维甲酸X受体激活通路（FXR-RXR Activation）、内源性凝血酶原激活通路，以及归入IPA"生物学功能分类"的"凝血功能（Blood Clotting）"。每个工作表均提供以下信息：基因符号、Entrez基因名称、以log₂比值（Rf+/Rf-，其中Rf+代表核黄素拯救组，Rf-代表核黄素缺陷组）表示的基因表达量，以及RefSeq蛋白ID或Entrez基因ID。（文件格式：XLSX，大小：27 KB）