p21 peptide simulation data. Dataset includes imaged trajectory files for the five Pep-GaMD simulations runs. We have also provided the topology and the pdb file.

Insights into the structural dynamic mechanism of PC1 activation by TA peptide agonists p9, p17 and p21 to provide an in-depth understanding that will facilitate development of therapeutics targeting PC1 for ADPKD by targeting PC1treatment.

本数据集旨在解析TA肽激动剂p9、p17及p21激活多囊蛋白1（PC1）的结构动力学机制，以获得深度认知，助力开发以PC1为靶点、用于常染色体显性多囊肾病（Autosomal Dominant Polycystic Kidney Disease, ADPKD）治疗的相关疗法。