Dataset related to article "Computed tomography based radiomic signature as predictive of survival and local control after stereotactic body radiation therapy in pancreatic carcinoma"

PURPOSE: To appraise the ability of a radiomics signature to predict clinical outcome after stereotactic body radiation therapy (SBRT) for pancreas carcinoma. METHODS: A cohort of 100 patients was included in this retrospective, single institution analysis. Radiomics texture features were extracted from computed tomography (CT) images obtained for the clinical target volume. The cohort of patients was randomly divided into two separate groups for the training (60 patients) and validation (40 patients). Cox regression models were built to predict overall survival and local control. The significant predictors at univariate analysis were included in a multivariate model. The quality of the models was appraised by means of area under the curve and concordance index. RESULTS: A clinical-radiomic signature associated with Overall Survival (OS) was found significant in both training and validation sets (p = 0.01 and 0.05 and concordance index 0.73 and 0.75 respectively). Similarly, a signature was found for Local Control (LC) with p = 0.007 and 0.004 and concordance index 0.69 and 0.75. In the low risk group, the median OS and LC in the validation group were 14.4 and 28.6 months while in the high-risk group were 9.0 and 17.5 months respectively. CONCLUSION: A CT based radiomic signature was identified which correlate with OS and LC after SBRT and allowed to identify low and high-risk groups of patients.研究目的：评估放射组学特征预测胰腺癌立体定向体部放射治疗（stereotactic body radiation therapy, SBRT）后临床结局的能力。 研究方法：本回顾性单中心分析纳入100例患者队列。从针对临床靶区获取的计算机断层扫描（computed tomography, CT）图像中提取放射组学纹理特征。将患者队列随机划分为训练组（60例）与验证组（40例）。构建Cox回归模型以预测总生存期（Overall Survival, OS）与局部控制率（Local Control, LC）。将单因素分析中具有统计学意义的预测因子纳入多因素模型。采用曲线下面积与一致性指数评估模型的性能。 研究结果：在训练集与验证集中，与总生存期相关的临床-放射组学特征均具有统计学意义（训练集p=0.01，验证集p=0.05，一致性指数分别为0.73与0.75）。类似地，针对局部控制率的特征亦具有统计学意义，p值分别为0.007与0.004，一致性指数分别为0.69与0.75。在低风险组中，验证队列的中位总生存期与中位局部控制期分别为14.4个月与28.6个月；而高风险组则分别为9.0个月与17.5个月。 研究结论：本研究鉴定出一种基于计算机断层扫描的放射组学特征，该特征与胰腺癌立体定向体部放射治疗后的总生存期及局部控制率显著相关，并可用于区分患者的高低风险组别。