Lacrimal Gland from Sjögren's disease animal model

The lacrimal gland (LG) is the major source of aqueous tears, and insufficient LG secretion leads to aqueous-deficient dry eye (ADDE) disease. To provide a foundational description of LG's protein expression patterns, we prepared protein extracts of LGs from a wild-type and an ADDE mouse model and analyzed the proteome by quantitative mass spectrometry.

泪腺（lacrimal gland, LG）是水性泪液的主要来源，其分泌不足会引发水性泪液缺乏型干眼症（aqueous-deficient dry eye, ADDE）。为阐明LG的蛋白质表达模式的基础特征，本研究从野生型小鼠及ADDE模型小鼠的泪腺中制备了蛋白提取物，并通过定量质谱分析法对其蛋白质组进行了分析。