Clinical characteristics of WTCCC/UKRAGG cases and controls included in modelling.

Data are number (%) unless otherwise stated. The following data are missing from WTCCC: gender in 2 cases and 169 controls; RF status in 5 cases; ACPA status in 290 cases; age of onset missing/inaccurate in 63 cases; erosive status in 96 cases; smoking status in 76 male cases, 204 female cases and 3 female controls. The following data are missing from UKRAGG: gender in 14 controls; RF status in 60 cases; ACPA status in 844 cases; age of onset missing/inaccurate in 93 cases; erosive status in 1,432 cases; nodular status in 378 cases; smoking status in 226 male cases, 513 female cases, 274 male controls and 284 female controls.a = % of males that are ever smokers;b = % of females that are ever smokers.除非另有说明，所有数据均以例数（百分比）形式呈现。WTCCC数据集存在以下缺失数据情况：2例病例与169例对照的性别信息缺失；5例病例的类风湿因子（Rheumatoid Factor, RF）状态缺失；290例病例的抗瓜氨酸化蛋白抗体（Anti-Citrullinated Protein Antibodies, ACPA）状态缺失；63例病例的发病年龄信息缺失或不准确；96例病例的侵蚀性关节状态缺失；76例男性病例、204例女性病例及3例女性对照的吸烟状态缺失。UKRAGG数据集存在以下缺失数据情况：14例对照的性别信息缺失；60例病例的RF状态缺失；844例病例的ACPA状态缺失；93例病例的发病年龄信息缺失或不准确；1432例病例的侵蚀性关节状态缺失；378例病例的结节状态缺失；226例男性病例、513例女性病例、274例男性对照及284例女性对照的吸烟状态缺失。a = 既往吸烟者占男性人群的比例；b = 既往吸烟者占女性人群的比例。