Gene expression alternations in the offspring liver from chromium restriction diet dams. Mus musculus

Maternal chromium restriction may disturb susceptibility in offspring. Liver from maternal chromium diet has 264 up- and 199 down- regulated genes, compared to control. Especially, Insulin signaling pathway and WNT pathway were affected. Overall design: We performed microarray analyses of offspring liver from chromium restriction dams and control diet dams at 32 week (n=3 per group).

母体铬限制可干扰子代的易感性。与对照组相比，母体铬限制饮食组的子代肝脏组织中存在264个上调基因与199个下调基因。尤为值得注意的是，胰岛素信号通路与WNT信号通路受到显著影响。整体实验设计：我们对32周龄的铬限制母鼠及其对照饮食母鼠的子代肝脏组织开展了基因芯片分析，每组n=3。