The GPR84 molecule is a mediator of a subpopulation of retinal microglia that promote TNF/IL-1α expression via the rho-ROCK pathway after optic nerve injury (bulk RNA-Seq). The GPR84 molecule is a mediator of a subpopulation of retinal microglia that promote TNF/IL-1α expression via the rho-ROCK pathway after optic nerve injury (bulk RNA-Seq)

We show that microglial gene expression patterns gradually change during RGC degeneration induced by optic nerve injury. Overall design: Examination of 4 different timepoint in Iba1-positive retinal cells under optic nerve injury in mice本研究表明，在视神经损伤诱导的视网膜神经节细胞（Retinal Ganglion Cell, RGC）变性过程中，小胶质细胞（microglia）的基因表达模式会逐渐发生改变。实验整体设计：对小鼠视神经损伤模型中离子钙结合衔接分子1（Ionized calcium-binding adapter molecule 1, Iba1）阳性视网膜细胞的4个不同时间节点开展检测。