AS01-adjuvanted vaccine promotes functional and epigenetic modifications in monocytes [scATAC-seq]
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HBS/AS01 adjuvanted vaccine induces changes in the chromatin structure in monocyte population impacting their gene expression, an effect that lasts until 6 months post vaccination frozen PBMCS isolated at D32, D44, D60, D180 post dose 2 after HBS/AS01 vaccination were depleted from CD3+ cells and processed via single cell ATACseq *************************************************************** Submitter states that missing raw files are due to patient privacy concerns. ***************************************************************
HBS/AS01佐剂疫苗可诱导单核细胞群体的染色质结构发生改变，进而调控其基因表达，该效应可持续至疫苗接种后6个月。本研究所用样本为经HBS/AS01疫苗接种第二剂后第32天（D32）、第44天（D44）、第60天（D60）及第180天（D180）采集的冻存外周血单个核细胞（Peripheral Blood Mononuclear Cells, PBMCs），上述样本已完成CD3+细胞剔除处理，并通过单细胞ATAC测序（single cell ATACseq）进行流程化分析。 *************************************************************** 提交者声明，原始数据文件缺失系出于患者隐私保护相关考量。 ***************************************************************
