Young infants exhibit distinct antibody and cellular immune responses to SARS-CoV-2

Complete dataset associated with manuscript "Young infants exhibit distinct antibody and cellular immune responses to SARS-CoV-2". All samples arranged by their nomenclature in the paper (infants I1-4; mothers M1-3; fathers F1-4; PCR-confirmed adult controls C1-10; pre-pandemic serum samples PP1-PP9). The folder "ELISA serum and saliva" contains original OD600nm data, and relative units for LIPS (Luciferase ImmunoPrecipitation System) assays as indicated, and corresponds to Fig. 1A-D & Fig. S1 in manuscript. The folder "Neutralisation" contains data describing percentage of SARS-CoV-2 infected cells relative to control wells containing virus only (no sera), and corresponds to Fig. 1E-F & Fig. S2. The folder "ELISpot" contains SFU/million PBMC data (after background unstimulated subtraction) and corresponds to Fig. 2A and S3A-B. The folder "Intracellular Cytokine Staining FCS files" contains original FACS acquisition data (with compensation controls) in folders per each experiment and corresponds to Fig. 2B-F and Fig. S3C-F.

本数据集配套于学术论文"Young infants exhibit distinct antibody and cellular immune responses to SARS-CoV-2"，所有样本均依照论文中的命名规范进行编排：婴儿组I1-4、母亲组M1-3、父亲组F1-4、经聚合酶链式反应（Polymerase Chain Reaction，PCR）确认的成年对照组C1-10、大流行前血清样本PP1-PP9。「ELISA血清与唾液」文件夹内含原始OD600nm检测数据，以及标注清晰的荧光素酶免疫沉淀系统（Luciferase ImmunoPrecipitation System，LIPS）检测相对活性单位，对应论文中的图1A-D及补充图S1。「中和实验」文件夹内含以仅含病毒（无血清）的对照孔为参照的严重急性呼吸综合征冠状病毒2（SARS-CoV-2）感染细胞百分比数据，对应论文中的图1E-F及补充图S2。「ELISpot实验」文件夹内含扣除本底未刺激组后的斑点形成单位（Spot Forming Unit，SFU）/百万外周血单个核细胞（Peripheral Blood Mononuclear Cell，PBMC）数据，对应论文中的图2A及补充图S3A-B。「细胞内细胞因子染色FCS文件」文件夹内含各实验分组的流式细胞仪（Fluorescence Activated Cell Sorter，FACS）原始采集数据（含补偿对照样本），对应论文中的图2B-F及补充图S3C-F。