ATN 071 HIV Viral Load and CD4 History Dataset in Neurocognitive Assessment in Youth Initiating HAART

Data from HIV Viral Load and CD4 History Form [CRF f20]
Study Description
A prospective cohort study comparing neurocognitive functioning in four groups of youth, ages 18-24 years, with behaviorally acquired HIV infection: two groups with CD4+ T-cells greater than 350 cells/mm3 and HIV RNA equal to or greater than 1,000 copies/ml - one initiating early highly active antiretroviral therapy (HAART) (Group 1), the other not initiating treatment (Group 2); and two groups with CD4+ T-cells less than 350 cells/mm3 - one initiating HAART according to then current DHHS guidelines (Group 3), the other not initiating treatment (Group 4). Groups 2 and 3 represented standard of care. The study provided preliminary data to test the hypothesis that initiating HAART earlier than DHHS guidelines suggested at that time resulted in better neurocognitive function in comparison with no treatment or treatment initiated according to DHHS recommendations. Youth ages 18-24 years with behaviorally acquired HIV infection

本数据集来源于HIV病毒载量与CD4细胞计数历史表单[病例报告表（Case Report Form，CRF）f20]。
研究描述
本研究为一项前瞻性队列研究，针对18~24岁经性行为获得人类免疫缺陷病毒（HIV）感染的青年群体，设置四组受试者并比较其神经认知功能：
其中两组受试者的CD4+T淋巴细胞计数＞350个/mm³，且HIV RNA载量≥1000拷贝/ml：一组早期启动高效抗反转录病毒治疗（Highly Active Antiretroviral Therapy，HAART）（第1组），另一组未启动治疗（第2组）；
另外两组受试者的CD4+T淋巴细胞计数＜350个/mm³：一组按照当时现行的美国卫生与公众服务部（Department of Health and Human Services，DHHS）指南启动HAART治疗（第3组），另一组未启动治疗（第4组）。
第2组与第3组代表当时的标准治疗方案。本研究通过前期数据验证了如下假说：相较于未接受治疗或按照DHHS指南启动治疗的受试者，提前启动HAART治疗（早于当时DHHS指南推荐时机）可获得更优的神经认知功能。本研究纳入的受试者为18~24岁经性行为感染HIV的青年。