Cell type distribution in female and male mouse brains / Pdyn_GFP_M5_191222

This project proposes to establish an Anatomical Collaboratory for Systematic Atlasing of Cell-Type Distribution and Morphology in female and male brain. This Collaboratory will apply standardized, unbiased and largely automated methods developed in the group’s laboratories to atlas the distribution and morphology of >80 molecularly defined cell classes and cell type across all regions of the female and male brain. This work will yield the most comprehensive characterization of cell type anatomy in the mammalian brain to date, establishing a structural basis for building an integrated Cell Type Brain Atlas.

本项目拟搭建解剖学协作研究平台，以系统性绘制雌性与雄性大脑的细胞类型分布与形态图谱。该协作平台将采用本课题组实验室开发的标准化、无偏倚且高度自动化的研究方法，对雌性与雄性大脑全脑各区域内的80余个经分子标记定义的细胞类群及细胞类型的分布与形态开展图谱绘制工作。本研究将产出迄今为止针对哺乳动物大脑细胞类型解剖结构最为全面的特征刻画成果，并为构建整合式细胞类型大脑图谱（Cell Type Brain Atlas）奠定结构基础。