Hospital Summary Dataset in Life After Pediatric Sepsis Evaluation

This file includes hospital summary information
Study Description
The purpose of this prospective observational study was to describe short and long-term outcomes among children surviving septic shock. LAPSE investigated the intensity and duration of sepsis-associated morbidity that persists following the acute septic event. LAPSE described the post sepsis illness trajectory through Health Related Quality of Life (HRQL) and subject functional status (FS). LAPSE examined organ dysfunction, as well as individual and environmental characteristics that influenced these outcomes. We hypothesized that variation of HRQL and FS would be seen following survival of severe sepsis, enabling development of composite outcome measures for future trials of pediatric sepsis. This study found that 11% of the children died within 3 months of their septic shock episode. Additionally, duration of stay, cumulative vasoactive-inotropic scores, duration of mechanical ventilation, and other factors were associated with adverse outcomes. This study enrolled infants and children with community acquired infection and severe sepsis. Subjects were evaluated in detail to enable assessment of life quality as well as survival outcomes.

本文件包含医院汇总信息。
研究描述：本项前瞻性观察性研究旨在明确感染性休克存活儿童的短期与长期转归。LAPSE旨在探究急性脓毒症事件后仍持续存在的脓毒症相关并发症的严重程度与持续时长。该研究通过健康相关生活质量（Health Related Quality of Life, HRQL）与受试者功能状态（Functional Status, FS）阐明脓毒症后患者的疾病轨迹，同时分析了器官功能障碍以及影响上述转归的个体与环境特征。我们提出假设：重症脓毒症存活患者的健康相关生活质量与功能状态存在异质性，可为未来儿童脓毒症临床试验的复合结局指标开发提供依据。本研究发现，11%的儿童在感染性休克发作后3个月内死亡。此外，住院时长、累计血管活性肌力药物评分、机械通气时长及其他因素与不良转归相关。本研究纳入了罹患社区获得性感染与重症脓毒症的婴幼儿及儿童，对受试者进行了详细评估，以评估其生活质量与生存转归。