Host-Specific Nucleotide Divergence in MERS-CoV Spike RBD: Primary Hydrogen-Bond and Salt-Bridge Residues in Human vs. Camel Isolates

This dataset contains aligned MERS-CoV Spike S1 subunit sequences from <b>272 human</b> and <b>391 camel</b> isolates, along with comprehensive nucleotide-level analyses of codons corresponding to <b>primary hydrogen-bonding (Y499, D510, E513)</b> and <b>salt-bridge (E536, D537, D539, R542)</b> residues critical for DPP4 binding. Includes raw alignments (.aln), reference sequence, variant frequency tables, and Fisher’s exact test results with FDR correction. This resource enables investigation of host-driven adaptation in zoonotic coronaviruses.<br>

本数据集包含经序列比对的中东呼吸综合征冠状病毒（MERS-CoV）刺突蛋白S1亚基（Spike S1 subunit）序列，涵盖**272株人类**与**391株骆驼**分离株；同时针对与二肽基肽酶4（DPP4）结合至关重要的**主要氢键作用（Y499、D510、E513）**与**盐桥作用（E536、D537、D539、R542）**对应的氨基酸残基密码子，开展了全面的核苷酸水平分析。数据集包含原始序列比对文件（.aln）、参考序列、变异频率表，以及经错误发现率（FDR）校正的费希尔精确检验结果，可用于探究人畜共患冠状病毒的宿主驱动适应性演化。