Exosomes - Differential miRNA expression profile and proteome in plasma exosomes from patients with paroxysmal nocturnal hemoglobinuria

Quantitative Proteomic analysis of human plasma exosomes using TMT isobaric tag labelling and nanoLC-Orbitrap. Nine patient samples and five control samples are analyzed to assess the proteome changes due to the pathology

采用串联质量标签（TMT）同量异位素标记法结合纳升液相色谱-轨道阱质谱（nanoLC-Orbitrap）联用技术，对人类血浆外泌体（exosomes）进行定量蛋白质组学分析。本研究纳入9例患者样本与5例对照样本，旨在评估病理状态下的蛋白质组变化。