# Supplementary Data for the Paper "Sexual size dimorphism in mammals is associated with changes in the size of gene families related to brain development"

# Supplementary Data for the Paper "Sexual size dimorphism in mammals is associated with changes in the size of gene families related to brain development"

**Author:** Benjamin Padilla-Morales
**Affiliation:** University of Bath
**Email:** [e-mail]

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## Overview

This repository contains supplementary tables for the article "Sexual size dimorphism is associated with gene family contractions in brain development in mammals" The study investigates gene family size expansions and contractions in relation to brain development and sexual size dimorphism in mammals, employing a comparative genomics approach. Subsequently, we perform a Gene Ontology (GO) enrichment analysis on the gene families experiencing expansion and contraction to uncover the functional significance of associated genes. Additionally, we conduct a gene expression analysis of genes linked to these families to determine their over expression in brain tissue, showing the potential influence of sexual selection on the mammalian brain.

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## Contents

- **Supplementary Figures:** Supplementary figures with corresponding descriptions.
- **Supplementary data 1:** Output from gene family expansion/contraction analysis for sexual size dimorphism, along with their corresponding statistical significance per gene family.
- **Supplementary data 2:** Average gene expression levels of brain areas and other tissues for adults and fetuses.
- **Supplementary data 3:** Entrez Gene ID to GO category per gene with foldchange results and p-values
- **Supplementary data 4:** List of species used in the analysis with phenotypical data, including sources.
- **Supplementary data 5:** List of sequences with respective species used for the orthology mapping analysis and links to ftp with download code.
- **Supplementary data 6:** Output from gene family expansion/contraction analysis including zero variance gene families for sexual size dimorphism.
- **Supplementary data 7:** List of species with encephalization index used in this research, along with references.
- **Supplementary table 1:** List of terms, abbreviations, and descriptions of brain structures used for sex-biased gene expression in temporal brain analysis.

For any questions or inquiries, please contact Benjamin Padilla-Morales at the provided email address.

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# 论文《哺乳动物的性体型二态性与脑发育相关基因家族大小变化的关联》补充数据

**作者：本杰明·帕迪利亚-莫拉莱斯（Benjamin Padilla-Morales）**
**所属机构：巴斯大学（University of Bath）**
**邮箱：[e-mail]**

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## 概述
本仓库包含论文《哺乳动物脑发育相关基因家族收缩与性体型二态性（sexual size dimorphism）存在关联》的补充表格。本研究采用比较基因组学方法，探究哺乳动物脑发育相关基因家族的扩张与收缩情况，及其与性体型二态性的关联。随后，研究团队对发生扩张和收缩的基因家族开展基因本体（Gene Ontology, GO）富集分析，以揭示相关基因的功能意义。此外，本研究还对上述基因家族关联的基因进行基因表达分析，以明确其在脑组织中的过表达情况，进而展现性选择对哺乳动物大脑的潜在影响。

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## 内容清单
- **补充图**：附带对应说明的补充插图
- **补充数据集1**：针对性体型二态性的基因家族扩张/收缩分析结果，以及各基因家族对应的统计学显著性数据
- **补充数据集2**：成体与胎儿的脑区及其他组织的平均基因表达水平
- **补充数据集3**：每个基因的Entrez基因ID（Entrez Gene ID）与GO分类的对应关系，附带倍数变化结果与p值
- **补充数据集4**：本分析所用物种列表及表型数据，包含数据来源
- **补充数据集5**：用于直系同源映射分析（orthology mapping analysis）的序列列表、对应物种，以及含下载代码的FTP链接
- **补充数据集6**：针对性体型二态性的基因家族扩张/收缩分析结果，包含方差为零的基因家族
- **补充数据集7**：本研究使用的具脑化指数（encephalization index）的物种列表，附带参考文献
- **补充表1**：用于颞脑区域性别偏倚基因表达（sex-biased gene expression）分析的脑结构术语、缩写及说明列表

如有任何疑问或咨询，请联系本杰明·帕迪利亚-莫拉莱斯，邮箱地址如前所述。

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