Table 3_The triglyceride glucose-body mass index is positively associated with higher risk of hypertension in rural southwest Chinese population: a cross sectional study.doc

BackgroundInsulin resistance (IR) has been shown to be associated with hypertension. The triglyceride-glucose body mass index (TyG-BMI) has emerged as a novel surrogate marker for assessing IR. This study aimed to investigate the association between the TyG-BMI index and hypertension among adults in rural southwest China using a cross-sectional study.
MethodWe recruited 2,998 people between the ages of 30 and 79 from Rongchang, Chongqing municipality, southwest China, as part of The China Multi-Ethnic Cohort Study, considered the largest cohort study in southwest China. Logistic regression model, restricted cubic spline (RCS) model and receiver operating characteristic (ROC) were applied to estimate the association between the TyG-BMI index and hypertension. Moreover, subgroup and sensitivity analyses were undertaken to check the consistency of the outcomes.
ResultsA total of 2,998 participants were included in the present study, with a hypertension prevalence of 39.93%. After adjusting for confounding factors, the ORs of hypertension in Q2, Q3, Q4 were 1.641 (1.277–2.109), 1.768 (1.371–2.281), 2.463 (1.794–3.382) compared with the lowest quartile (Q1), respectively. RCS indicated that the TyG-BMI index was nonlinearly associated with hypertension (Pfor overall < 0.001, Pfor nonlinear = 0.046). The ROC analysis indicated that the TyG-BMI index had a 64.1% (AUC: 0.641, 95% CI: 0.621–0.661) ability to distinguish hypertension. Subgroup analysis in participants without diabetes, dyslipidemia, hyperuricemia and central obesity as well as sensitivity analyses also demonstrated the similar relationship between the TyG-BMI index and hypertension.
ConclusionThe current study demonstrates that the TyG-BMI index is associated with higher risk of hypertension among rural adults in southwest China. Lifestyle modifications, including weight control, vigorous physical activity and healthy dietary pattern can help improve IR and prevent hypertension.

**背景** 胰岛素抵抗（Insulin resistance, IR）已被证实与高血压存在关联。甘油三酯-葡萄糖体重指数（triglyceride-glucose body mass index, TyG-BMI）已成为评估IR的新型替代标志物。本研究旨在通过横断面研究设计，探讨中国西南农村成年人群中TyG-BMI指数与高血压的关联。
**方法** 本研究作为中国多民族队列研究（China Multi-Ethnic Cohort Study，该研究为中国西南地区规模最大的队列研究）的子项目，从中国西南重庆市荣昌区招募了2998名年龄介于30~79岁的受试者。采用logistic回归模型、限制性立方样条（restricted cubic spline, RCS）模型及受试者工作特征（receiver operating characteristic, ROC）曲线分析，评估TyG-BMI指数与高血压的关联。此外，通过亚组分析与敏感性分析验证研究结果的一致性。
**结果** 本研究最终纳入2998名受试者，高血压患病率为39.93%。以最低四分位数组（Q1）为参照，校正混杂因素后，Q2、Q3、Q4组高血压的比值比（odds ratio, OR）分别为1.641（95%置信区间：1.277~2.109）、1.768（95%置信区间：1.371~2.281）、2.463（95%置信区间：1.794~3.382）。RCS分析显示，TyG-BMI指数与高血压呈非线性关联（整体检验P<0.001，非线性检验P=0.046）。ROC分析表明，TyG-BMI指数区分高血压的曲线下面积（AUC）为0.641（95%置信区间：0.621~0.661）。针对无糖尿病、血脂异常、高尿酸血症及中心性肥胖的受试者开展的亚组分析与敏感性分析，同样证实了TyG-BMI指数与高血压之间的相似关联。
**结论** 本研究表明，在中国西南农村成年人群中，TyG-BMI指数升高与高血压风险增加显著相关。通过控制体重、坚持剧烈体力活动及遵循健康饮食模式等生活方式干预措施，有助于改善IR并预防高血压。