Analysis of crossover interference in <i>msh4-R676W</i> by coefficient of co-incidence.

The Coefficient of Coincidence (COC) for pairs of adjacent genetic intervals on Chromosomes III, VII and VIII in the NHY strain background was calculated from the ratio of double crossovers observed to that expected using RANA software [24]. Two-tailed p values were calculated using the binomial probabilities calculator with normal distribution. Statistically significant p values (p<0.05) suggest the presence of interference (I) in the genetic interval. Wild-type data are from [21].本研究针对NHY菌株背景下三号、七号与八号染色体上的相邻遗传区间，计算了其并发系数（Coefficient of Coincidence, COC）：该系数以RANA软件[24]计算得到，取值为观测到的双交换数与预期双交换数的比值。随后采用基于正态分布的二项概率计算器计算双侧p值。当p值具有统计学显著性（p<0.05）时，表明对应遗传区间存在干涉（I）。野生型数据引自文献[21]。