Supplementary information files for "Association between ACE (I/D) polymorphism and essential hypertension (EH): an updated systematic review and meta-analysis"

Supplementary files for article "Association between ACE (I/D) polymorphism and essential hypertension (EH): an updated systematic review and meta-analysis"

Background: Essential hypertension (EH) refers to elevated arterial blood pressure with unknown etiology, which becomes more prevalent with age. Although the D allele of the ACE (I/D) polymorphism has been linked to EH, this association is not consistent across global populations. This systematic review and meta-analysis examined the relationship between the ACE (I/D) polymorphism and EH in diverse populations to determine the comparability of effect sizes and explore potential implications for public health planning.

Methods: Case–control and cohort studies published in the last 20 years were reviewed from the main databases (PubMed, Scopus and Embase) using specific inclusion and exclusion criteria. Genotype data were used in meta-analyses using different genetic models.
Results: Twenty-two studies with 7690 participants (3886 cases and 3804 controls) were included. Significant associations were observed between the ACE D allele and EH across allelic (OR = 1.37, 95% CI: 1.14–1.63), recessive (OR = 1.61, 95% CI: 1.21–2.13), dominant (OR = 1.37, 95% CI: 1.13–1.67), and homozygote (OR = 1.79, 95% CI: 1.31–2.45) models. Subgroup analyses showed significant associations in Indian and European populations, while African, Middle Eastern and Hispanic groups showed no statistically significant associations.
Conclusions: The findings support a significant association between the ACE D allele and EH in several populations, though associations vary by ethnicity.

© The Author(s), CC-BY 4.0

论文《血管紧张素转换酶（Angiotensin-Converting Enzyme, ACE）（I/D）基因多态性与原发性高血压（Essential Hypertension, EH）的关联：一项更新的系统评价与荟萃分析》的补充文件

研究背景：原发性高血压（EH）指病因未明的动脉血压升高，其患病率随年龄增长而升高。尽管ACE（I/D）基因多态性的D等位基因已被证实与EH存在关联，但这一关联在全球不同人群中并不一致。本项系统评价与荟萃分析旨在探究不同人群中ACE（I/D）基因多态性与EH的关联，以明确效应量的可比性，并探索其对公共卫生规划的潜在意义。

研究方法：本研究通过特定的纳入与排除标准，检索了近20年发表于主要数据库（PubMed、Scopus及Embase）中的病例对照研究与队列研究。荟萃分析采用多种遗传模型对基因型数据进行分析。

研究结果：最终纳入22项研究，共涉及7690名受试者（3886名病例组受试者与3804名对照组受试者）。在等位基因模型（比值比OR=1.37，95%置信区间CI：1.14~1.63）、隐性模型（OR=1.61，95%CI：1.21~2.13）、显性模型（OR=1.37，95%CI：1.13~1.67）及纯合子模型（OR=1.79，95%CI：1.31~2.45）中，均观察到ACE D等位基因与EH存在显著关联。亚组分析显示，印度人群与欧洲人群中存在显著关联，而非洲、中东及西班牙裔人群则未观察到具有统计学意义的关联。

研究结论：本研究结果支持在部分人群中ACE D等位基因与EH存在显著关联，尽管该关联因种族而异。

© 作者，CC-BY 4.0